Publications - The Sebastian Lab

022

NOTCH1 reverses immune suppression in small cell lung cancer through reactivation of STING

Kim YS, Nabet BY, Cortez BN, Sun NY, Sebastian R, Redon CE, Ray A, Liu L, Ishola AA, Loew S, Dhall A, Sindiri S, Gayevskiy V, Lee MJ, Rastogi S, Sato N, Kedei N, Andresson T, Das S, Kumar S, Bers AE, Zhang H, Chiappori A, Gopal P, Abazeed ME, Chen H, Aladjem MI, Pommier Y, Velez MJ, Shames DS, Roper N.

J Clin Invest. 2025 Jul 8;. doi: 10.1172/JCI185423. [Epub ahead of print] PubMed PMID: 40627448.

021

Selective interactions at pre-replication complexes categorize baseline and dormant origins.

Thakur BL, Redon CE, Fu H, Sebastian R, Kusi NA, Zhuang SZ, Pongor LS, Bohr VA, Aladjem MI.

Nat Commun. 2025 May 3;16(1):4140. doi: 10.1038/s41467-025-59509-4. PubMed PMID: 40319014; PubMed Central PMCID: PMC12049448.

020

Mechanism for local attenuation of DNA replication at double-strand breaks.

Sebastian R, Sun EG, Fedkenheuer M, Fu H, Jung S, Thakur BL, Redon CE, Pegoraro G, Tran AD, Gross JM, Mosavarpour S, Kusi NA, Ray A, Dhall A, Pongor LS, Casellas R, Aladjem MI.

Nature. 2025 Mar;639(8056):1084-1092. doi: 10.1038/s41586-024-08557-9. Epub 2025 Feb 19. PubMed PMID: 39972127.

019

A dual role of Cohesin in DNA DSB repair.

Fedkenheuer M, Shang Y, Jung S, Fedkenheuer K, Park S, Mazza D, Sebastian R, Nagashima H, Zong D, Tan H, Jaiswal SK, Fu H, Cruz A, Vartak SV, Wisniewski J, Sartorelli V, O'Shea JJ, Elnitski L, Nussenzweig A, Aladjem MI, Meng FL, Casellas R.

Nat Commun. 2025 Jan 20;16(1):843. doi: 10.1038/s41467-025-56086-4. PubMed PMID: 39833168; PubMed Central PMCID: PMC11747280.

018

Acetalax (Oxyphenisatin Acetate, NSC 59687) and Bisacodyl Cause Oncosis in Triple-Negative Breast Cancer Cell Lines by Poisoning the Ion Exchange Membrane Protein TRPM4.

Mizunuma M, Redon CE, Saha LK, Tran AD, Dhall A, Sebastian R, Taniyama D, Kruhlak MJ, Reinhold WC, Takebe N, Pommier Y.

Cancer Res Commun. 2024 Aug 1;4(8):2101-2111. doi: 10.1158/2767-9764.CRC-24-0093. PubMed PMID: 39041239; PubMed Central PMCID: PMC11322923.

017

Microenvironment shapes small-cell lung cancer neuroendocrine states and presents therapeutic opportunities.

Desai P, Takahashi N, Kumar R, Nichols S, Malin J, Hunt A, Schultz C, Cao Y, Tillo D, Nousome D, Chauhan L, Sciuto L, Jordan K, Rajapakse V, Tandon M, Lissa D, Zhang Y, Kumar S, Pongor L, Singh A, Schroder B, Sharma AK, Chang T, Vilimas R, Pinkiert D, Graham C, Butcher D, Warner A, Sebastian R, Mahon M, Baker K, Cheng J, Berger A, Lake R, Abel M, Krishnamurthy M, Chrisafis G, Fitzgerald P, Nirula M, Goyal S, Atkinson D, Bateman NW, Abulez T, Nair G, Apolo A, Guha U, Karim B, El Meskini R, Ohler ZW, Jolly MK, Schaffer A, Ruppin E, Kleiner D, Miettinen M, Brown GT, Hewitt S, Conrads T, Thomas A.

Cell Rep Med. 2024 Jun 18;5(6):101610. doi: 10.1016/j.xcrm.2024.101610. PubMed PMID: 38897168; PubMed Central PMCID: PMC11228806.

016

SIRT1 Prevents R-Loops during Chronological Aging by Modulating DNA Replication at rDNA Loci.

Thakur BL, Kusi NA, Mosavarpour S, Zhu R, Redon CE, Fu H, Dhall A, Pongor LS, Sebastian R, Indig FE, Aladjem MI.

Cells. 2023 Nov 15;12(22). doi: 10.3390/cells12222630. PubMed PMID: 37998365; PubMed Central PMCID: PMC10669956.

015

ATR inhibition augments the efficacy of lurbinectedin in small-cell lung cancer.

Schultz CW, Zhang Y, Elmeskini R, Zimmermann A, Fu H, Murai Y, Wangsa D, Kumar S, Takahashi N, Atkinson D, Saha LK, Lee CF, Elenbaas B, Desai P, Sebastian R, Sharma AK, Abel M, Schroeder B, Krishnamurthy M, Kumar R, Roper N, Aladjem M, Zenke FT, Ohler ZW, Pommier Y, Thomas A.

EMBO Mol Med. 2023 Aug 7;15(8):e17313. doi: 10.15252/emmm.202217313. Epub 2023 Jul 25. PubMed PMID: 37491889; PubMed Central PMCID: PMC10405061.

014

Convergence of SIRT1 and ATR signaling to modulate replication origin dormancy.

Thakur BL, Baris AM, Fu H, Redon CE, Pongor LS, Mosavarpour S, Gross JM, Jang SM, Sebastian R, Utani K, Jenkins LM, Indig FE, Aladjem MI.

Nucleic Acids Res. 2022 May 20;50(9):5111-5128. doi: 10.1093/nar/gkac299. PubMed PMID: 35524559; PubMed Central PMCID: PMC9122590.

013

Encounters in Three Dimensions: How Nuclear Topology Shapes Genome Integrity.

Sebastian R, Aladjem MI, Oberdoerffer P.

Front Genet. 2021;12:746380. doi: 10.3389/fgene.2021.746380. eCollection 2021. Review. PubMed PMID: 34745220; PubMed Central PMCID: PMC8566435.

012

Dynamics of replication origin over-activation.

Fu H, Redon CE, Thakur BL, Utani K, Sebastian R, Jang SM, Gross JM, Mosavarpour S, Marks AB, Zhuang SZ, Lazar SB, Rao M, Mencer ST, Baris AM, Pongor LS, Aladjem MI.

Nat Commun. 2021 Jun 8;12(1):3448. doi: 10.1038/s41467-021-23835-0. PubMed PMID: 34103496; PubMed Central PMCID: PMC8187443.

011

SCLC-CellMiner: A Resource for Small Cell Lung Cancer Cell Line Genomics and Pharmacology Based on Genomic Signatures.

Tlemsani C, Pongor L, Elloumi F, Girard L, Huffman KE, Roper N, Varma S, Luna A, Rajapakse VN, Sebastian R, Kohn KW, Krushkal J, Aladjem MI, Teicher BA, Meltzer PS, Reinhold WC, Minna JD, Thomas A, Pommier Y.

Cell Rep. 2020 Oct 20;33(3):108296. doi: 10.1016/j.celrep.2020.108296. PubMed PMID: 33086069; PubMed Central PMCID: PMC7643325.

010

Epigenetic Regulation of DNA Repair Pathway Choice by MacroH2A1 Splice Variants Ensures Genome Stability.

Sebastian R, Hosogane EK, Sun EG, Tran AD, Reinhold WC, Burkett S, Sturgill DM, Gudla PR, Pommier Y, Aladjem MI, Oberdoerffer P.

Mol Cell. 2020 Sep 3;79(5):836-845.e7. doi: 10.1016/j.molcel.2020.06.028. Epub 2020 Jul 9. PubMed PMID: 32649884; PubMed Central PMCID: PMC7483679.

009

Replication Stress Shapes a Protective Chromatin Environment across Fragile Genomic Regions.

Kim J, Sturgill D, Sebastian R, Khurana S, Tran AD, Edwards GB, Kruswick A, Burkett S, Hosogane EK, Hannon WW, Weyemi U, Bonner WM, Luger K, Oberdoerffer P.

Mol Cell. 2018 Jan 4;69(1):36-47.e7. doi: 10.1016/j.molcel.2017.11.021. Epub 2017 Dec 14. PubMed PMID: 29249653; PubMed Central PMCID: PMC5756112.

008

Transcription-associated events affecting genomic integrity.

Sebastian R, Oberdoerffer P.

Philos Trans R Soc Lond B Biol Sci. 2017 Oct 5;372(1731). doi: 10.1098/rstb.2016.0288. Review. PubMed PMID: 28847825; PubMed Central PMCID: PMC5577466.

007

Exposure to welding fumes activates DNA damage response and redox-sensitive transcription factor signalling in Sprague-Dawley rats.

Krishnaraj J, Kowshik J, Sebastian R, Raghavan SC, Nagini S.

Toxicol Lett. 2017 May 15;274:8-19. doi: 10.1016/j.toxlet.2017.04.001. Epub 2017 Apr 5. PubMed PMID: 28389379.

006

Molecular mechanism of Endosulfan action in mammals.

Sebastian R, Raghavan SC

J Biosci. 2017 Mar;42(1):149-153. doi: 10.1007/s12038-016-9655-4. Review. PubMed PMID: 28229974.

005

Induction of DNA damage and erroneous repair can explain genomic instability caused by endosulfan.

Sebastian R, Raghavan SC.

Carcinogenesis. 2016 Oct;37(10):929-40. doi: 10.1093/carcin/bgw081. Epub 2016 Aug 4. PubMed PMID: 27492056.

004

Endosulfan induces male infertility.

Sebastian R, Raghavan SC.

Cell Death Dis. 2015 Dec 17;6(12):e2022. doi: 10.1038/cddis.2015.368. PubMed PMID: 26673667; PubMed Central PMCID: PMC4720901.

003

Microhomology-mediated end joining is the principal mediator of double-strand break repair during mitochondrial DNA lesions.

Tadi SK, Sebastian R, Dahal S, Babu RK, Choudhary B, Raghavan SC.

Mol Biol Cell. 2016 Jan 15;27(2):223-35. doi: 10.1091/mbc.E15-05-0260. Epub 2015 Nov 25. PubMed PMID: 26609070; PubMed Central PMCID: PMC4713127.

002

Exposure to Endosulfan can result in male infertility due to testicular atrophy and reduced sperm count.

Sebastian R, Raghavan SC.

Cell Death Discov. 2015;1:15020. doi: 10.1038/cddiscovery.2015.20. eCollection 2015. PubMed PMID: 27551453; PubMed Central PMCID: PMC4979443.

001

Time-dependent predominance of nonhomologous DNA end-joining pathways during embryonic development in mice.

Chiruvella KK, Sebastian R, Sharma S, Karande AA, Choudhary B, Raghavan SC.

J Mol Biol. 2012 Mar 30;417(3):197-211. doi: 10.1016/j.jmb.2012.01.029. Epub 2012 Jan 27. PubMed PMID: 22306462.